Called in to investigate, Singaporean International Crimes Division (ICD) officer Serena Teo (Rebecca Lim) takes charge of a case across the border where a family has been slaughtered aboard a luxury yacht in Johor. Unfortunately for the fugitives, a shadowy government agent has ordered Agent Mahone to track down and kill the Fox River 8, and Mahone appears to be Michael's intellectual equal.A series of brutal murders, each sharing a signature MO, takes place across Malaysia and Indonesia. However, the paths of six of the wanted men converge in Utah, where they try to recover the loot stashed by the legendary hijacker D.B.
While Lincoln Burrows (Dominic Purcell) sticks close to his brother Michael, some of the ex-prisoners pursue their own agendas: John Abruzzi (Peter Stormare) wants to settle an old score Fernando Sucre (Amaury Nolasco) tries to halt the wedding of his beloved Maricruz (Camille Guaty) and Benjamin Miles "C-Note" Franklin (Rockmond Dunbar) and villainous Theodore "T-Bag" Bagwell (Robert Knepper) each try to reunite with their families. Disgraced prison guard Brad Bellick (Wade Williams) loses his job and joins the hunt for the Fox River 8 as a bounty hunter. Sara Tancredi (Sarah Wayne Callies), Michael's love interest and abettor, overdoses but survives, only to become a pawn in the political conspiracy as she tries to reunite with Michael. He begins his pursuit with a press conference to seek the public's help before taking a closer look at Michael's tattoos, which hold clues about his post-escape plans.
Led by Michael Scofield (Wentworth Miller), the mastermind behind the breakout, the escapees endeavor to stay ahead of the manhunt spearheaded by FBI Agent Alexander Mahone (William Fichtner). The second season kicks off with the eight inmates-turned-fugitives facing their first morning outside the walls of the Fox River State Penitentiary.
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